Epidemiological study of the prevalence of human papilomavirus suggestive fines in patients with oropharynx and/or mouth spinocellular carcinoma in a Roraima reference hospital
DOI:
https://doi.org/10.18227/hd.v3i1.7420Keywords:
Oropharynx cancer, mouth cancer, human papillomavirus, RoraimaAbstract
Introduction: Oropharynx and/or mouth spinocellular carcinoma (CEC-OB) has gained importance due to increased incidence rates and morbidity-mortality. It's associated with multiple factors, whose knowledge is important for early diagnosis and treatment. The emergence of human-papillomavirus (HPV) relationship, responsible for different sociodemographic-behavioral, morphological and symptomatological presentation, as well as better prognosis and therapeutic response is highlighted. Objective: To demonstrate the epidemiological profile of patients treated in Roraima from January/2016-January/2018 with CEC-OB and their findings suggestive of HPV, considering sociodemographic-behavioral factors and associated with the lesion. Methods: Qualitative-quantitative, retrospective and descriptive study. Sampling of 34 patients seen at the High Complexity Unit in Oncology at the General Hospital of Roraima. Analysis of information (gender, age, exposure to smoking and alcoholism, primary tumor location, clinical staging, presence of papilloma, koilocytosis, non-keratinization and P16INK4a expression) of patients medical records included in the proposed criteria after signing the Free and Informed Consent Form and approval by the Research Ethics Committee of the Federal University of Roraima for de number 2.442.554. Statistical analyzes were performed using EpiInfo® 7.1 Windows software (CDC, Atlanta, USA), Microsoft® Office Excel 2013 spreadsheets and Fisher's exact test in the analysis of contingency tables. Results: Of those included, 32% of the patients presented findings suggestive of HPV, with a standard profile, male gender, older than 40 years old, non-smoker, with advanced staging. Conclusion: Although the etiology of CEC-OB for many years has strong association with smoking and alcoholism, HPV has been showing important relation with this neoplasm since its presence was noted.
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